Please use this identifier to cite or link to this item:
http://paper.sci.ui.ac.id/jspui/handle/2808.28/144
Title: | Immunogenicity and Specificity of Anti recombinant Protein FimC-Salmonella typhimurium Antibody as a Model to Develop Typhoid Vaccine |
Authors: | Nurjayadi, Muktiningsih Apriyani, Dea Hasan, Umar Santoso, Imam Kurniadewi, Fera Kartika, Irma Ratna Agustini, Kurnia Puspasari, Fernita Natalia, Dessy Mangunwardoyo, Wibowo |
Keywords: | Salmonella typhimurium typhoid fever recombinant protein Fim-C-Salmonella typhimurium antibody recombinant vaccine |
Issue Date: | May-2015 |
Series/Report no.: | Volume 18; |
Abstract: | Salmonella typhimurium, that cause typhoid fever in mice was used as a model to study typhoid fever in humans. This study is aimed to determine the immunogenicity of recombinant protein of Fim-C-S. typhimurium and specificity of antibody anti-recombinant protein of Fim-C-S. typhimurium in ddY mice. The immunogenicity studies by ELISA indicated that recombinant protein of Fim-C-S. typhimurium evokes strong immune response in ddY mice, particularly in experiment group. The specificity evaluated by Western Immunobloting technique indicated that the antibody anti-recombinant protein of Fim-C-S. typhimurium can detect the 31 kDa of recombinant protein of Fim-C-S. typhimurium as an antigen. This data reported that recombinant protein of Fim-C-S. typhimurium is immunogenic and the antibody anti-recombinant protein of Fim-C-S. typhimurium is specific. The results of this study can be used as a model to develop recombinant vaccine candidate against typhoid. |
URI: | http://paper.sci.ui.ac.id/jspui/handle/2808.28/144 |
ISSN: | 18766196 |
Appears in Collections: | Journal Collection |
Files in This Item:
File | Description | Size | Format | |
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Wibowo.ProcediaChemistry.2016.pdf | 530,99 kB | Adobe PDF | View/Open Request a copy |
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