The Effect of Lovastatin Produced from Aspergillus flavus UICC 360 on Decreasing Cholesterol Level Blood (Rattus novergicus L.) Sprague Dawley strain

Abstract

Lovastatin is a competitive potential inhibitors of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase activity, which plays a role in cholesterol biosynthesis. In this study, rats were given extract lovastatin produced from the fermentation of Aspergillus flavus UICC 360 with various of doses (0.1, 0.2 and 0.4 mg/day) on the rats and examined the effect on serum total cholesterol, triglyceride, HDL and LDL in the blood of rats for 14 days treatment. The lovastatin dose was given at 0,1 mg/day not only decreased the total cholesterol, triglyseride and LDL, but also increased HDL eventhough was not sigificant, and the dose lovastatin given at 0.2 mg/day caused lowering the triglyceride (61.76%) at level (p <0.01) compared with negative control (21.28%), also the dose lovastatin given of 0.4 mg/day was able to decrease LDL levels (90%) at level (p<0,01) compared to the negative control (59.74%).