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http://paper.sci.ui.ac.id/jspui/handle/2808.28/25
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DC Field | Value | Language |
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dc.contributor.author | Nurfitriani, Risya | - |
dc.contributor.author | Abinawanto | - |
dc.contributor.author | Noviyanti, Rintis | - |
dc.contributor.author | Trianti, Lely | - |
dc.contributor.author | Nainggolan, Ita M. | - |
dc.date.accessioned | 2016-02-20T15:17:14Z | - |
dc.date.available | 2016-02-20T15:17:14Z | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 23391995 | - |
dc.identifier.other | 10.7454/mss.v18i2.3138 | en_US |
dc.identifier.uri | http://paper.sci.ui.ac.id/jspui/handle/2808.28/25 | - |
dc.description.abstract | Papua New Guinea (PNG) mutation is a point mutation that occurs in noncoding region of alpha globin clusters. Polymorphism promotes an additional recognition site for transcription factor (GATA-1) which presumably downregulates alpha globin synthesis. The aim of this research is to detect PNG mutation in other populations in Indonesia, thus the results will be used for completing standard diagnoses in detecting alpha thalassemia mutation based on ethnic background. The method used in detecting PNG mutation was PCR-RFLP. Detection of 399 samples (MCH <80 fL) using the PCR-RFLP method showed positive results for the Timika population. However, negative results were found in the Gayo, Sumba, and Ternate populations. PNG mutation frequency in the Timika (Papuan ethnic) population is 18.1% (28 of 154 samples). High malaria prevalence in East Indonesia did not show a positive correlation with the absence of PNG mutation in the Sumba and Ternate populations. The results showed that PNG mutation is only found groups that are infected with Plasmodium falciparum malaria, but not in Plasmodium vivax-infected ones. However, PNG mutation is common in the eastern Indonesia population. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Directorate of Research and Community and Enggagment | en_US |
dc.relation.ispartofseries | Volume 18;No. 2 | - |
dc.source | Makara Journal of Science Volume 18 No. 2 Hal. 47-51 (2014) | en_US |
dc.source.uri | http://journal.ui.ac.id/index.php/science/article/%20view/3138 | en_US |
dc.subject | ethnic | en_US |
dc.subject | malaria | en_US |
dc.subject | PNG mutation | en_US |
dc.subject | polymorphism | en_US |
dc.subject | population | en_US |
dc.subject | Plasmodium | en_US |
dc.title | Detection of Papua New Guinea Thalassemia Alpha Mutation in Gayo, Sumba, Ternate, and Timika Populations | en_US |
dc.type | Article | en_US |
Appears in Collections: | Journal Collection |
Files in This Item:
File | Description | Size | Format | |
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Abinawanto.Makara.2014.pdf | 1,16 MB | Adobe PDF | View/Open Request a copy |
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