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DC Field | Value | Language |
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dc.contributor.author | Maulidiyah | - |
dc.contributor.author | Cahyana, A. Herry | - |
dc.contributor.author | Suwarso, Wahyudi Priyono | - |
dc.contributor.author | Nurdin, Muhammad | - |
dc.date.accessioned | 2017-09-06T04:29:31Z | - |
dc.date.available | 2017-09-06T04:29:31Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0974-4304 | - |
dc.identifier.uri | http://paper.sci.ui.ac.id/jspui/handle/2808.28/315 | - |
dc.description.abstract | The purpose of this research was to isolate and elucidate structure of secondary metabolite compoundand to examine its cytotoxic activity of lichen Usnea blepharea Motyka obtained from Sulawesi – Indonesia. Powder of lichen was extracted using an acetone and continued separation by employing column chromatography (CC) with n-hexane and ethyl acetate solvents in a gradient elutionto produce a pure isolate. The structure was determined by UV-Vis, LC-MS, FTIR, 1H-NMR, 13C-NMR, 2D-NMR (HMBC, HMQC, COSY). The UV-Visspectrophotometer measurement was obtained maximumwavelength of 229 nm and 334 nm. The LC-MS data of this compound showed a molecular weight of680. The1H-NMR, 13C-NMR with DEPT spectrums showedthat this compound has 34 carbon atoms consisting of 2 methyl groups, 2 methoxy groups, 1 methyl group, 6 metin groups, 3 methylene groups, and 20 C quartener atoms. The2D-NMR (HMBC, HMQC,COSY) spectrums of analysis could be inferred that this compound is a Eumitrin A1 with the formula structure C34H32O15. The Eumitrin A1 was examined its cytotoxic activityagainst Murine Leukemia P388 cells with IC504.5 µg/mL (very active). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Sphinx Knowledge House | en_US |
dc.relation.ispartofseries | Volume 8;Issue 4 | - |
dc.source | http://sphinxsai.com/2015/ph_vol8_no4/2/(782-789)V8N4PT.pdf | en_US |
dc.source | International Journal of PharmTech Research Volume 8, Issue 4,, Pages 782-789, 13 August 2015 | en_US |
dc.subject | Eumitrin A1 | en_US |
dc.subject | Usnea blepharea Motyka | en_US |
dc.subject | Cytotoxic | en_US |
dc.subject | Murine Leukemia P388 Cells | en_US |
dc.title | Isolation and Structure Elucidation of Eumitrin A1 from Lichen Usnea blepharea Motyka and Its Cytotoxic Activity | en_US |
dc.type | Article | en_US |
Appears in Collections: | Journal Collection |
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File | Description | Size | Format | |
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A.HerryCahyana.IJOP.2015.pdf | 1,19 MB | Adobe PDF | View/Open Request a copy |
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